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Topotecan, Hycamtin
How often is this medicine given?
Topotecan is typically given weekly for three consecutive weeks out of
a four week cycle (on days 1, 8, and 15 of a 28 day cycle). Topotecan
may also be given for 5 consecutive days every 3-4 weeks, but this
is less common in our office. The most appropriate administration
regimen and the [...]
How does the medicine work?
Topotecan interferes with the function of an enzyme (called
topoisomerase I) used by cells to repair breaks in the DNA (the
machinery or “brain” that runs each cell) strand. When this happens,
the DNA strand breaks further and cannot be repaired resulting in
cell death. Topotecan is not able to discriminate between good cells
and cancer [...]